Swelling and pain in the vagina with nausea is considered to be inflammation of reproductive organs, ectopic pregnancy, menopausal syndrome and so on. 1. Inflammation of reproductive organs: Acute inflammation in the vagina or pelvis will lead to local itching, burning and pain, and at the same time cause chills, high fever, loss of appetite, nausea, headache and other symptoms. 2. Ectopic pregnancy: Pregnancy outside the uterus will grow abnormally, destroying mucosal tissues and blood vessels, such as abdominal pregnancy and cervical pregnancy. When blood accumulates in the rectal uterine pit, it can cause painful sensation of swelling in the anus, vagina and other parts of the body, accompanied by nausea, vomiting and other symptoms. 3. Menopause syndrome: female menopause estrogen will decline significantly, the lack of estrogen will make the vagina and urethra mucosa thin, causing vaginal dryness, pain, pain during sexual intercourse and other symptoms, in addition to menopause syndrome will also cause autonomic dysregulation and psychoneurological symptoms, loss of appetite, nausea, headache, anxiety and other symptoms. Vaginal distension and pain with nausea, there may also be other reasons, it is recommended to go to the hospital in time, improve the examination to clarify the cause, under the guidance of the doctor to give targeted treatment or treatment.