Acute coronary syndrome, myocarditis, pleurisy, bile reflux gastritis and other diseases can cause paroxysmal pain in the precordial region, which can be treated with medication and surgery. 1. Acute coronary syndrome: patients should rest in bed, closely monitor the electrocardiogram, blood pressure, heart rate, etc., dyspnea and reduced oxygen saturation, patients should be given continuous oxygen. Patients may also use antimyocardial ischemic drugs (nitroglycerin, metoprolol, aspirin, etc.) under the guidance of a doctor. Percutaneous coronary intervention and coronary artery bypass grafting can also be used for treatment. 2. Myocarditis: drugs that improve the energy metabolism of the patient’s myocardium, such as creatine phosphate, coenzyme Q, and vitamin supplements, such as vitamin C, can be used. 3. Pleurisy: caused by bacterial infection, penicillin, cefaclor, azithromycin, metronidazole and so on can be used. Tuberculous pleurisy can be treated with anti-tuberculosis drugs such as isoniazid, rifampicin, ethambutol and streptomycin. When the pain is severe, aspirin, indomethacin and other drugs can be used for pain relief. 4. Bile reflux gastritis: can use bismuth potassium citrate, aluminum thioglycollate and other gastric mucous membrane protection agents, domperidone, mosapride and other drugs to promote gastrointestinal dynamics, omeprazole, rabeprazole and other acid inhibitors for treatment. For more severe symptoms, gastrojejunostomy Roux-en-Y can be used. The above medications are recommended to be used under medical supervision. There are many causes of paroxysmal pain in the precordial region, and it is recommended to go to the hospital in time.