When there is persistent pain or severe pain caused by pathological fracture, we should be alert to tumor bone metastasis. 1. Persistent pain: the pain of bone metastasis is mostly persistent, and the pain is obvious at night, and there is no sudden and severe pain, the pain will be aggravated when the position is changed, and there will be obvious pressure pain when local pressure is exerted, and obvious bone metastasis foci can be found in bone scan. 2. Pathological fracture: when bone metastasis occurs, the bone with lesions will be more fragile, and a fracture can occur when there is a slight bump, and the fracture place is in severe pain, and obvious fracture lines can be seen in the imaging examination. When abnormal bone pain occurs in the body, timely examination should be carried out to see whether bone metastasis occurs, and if bone metastasis exists, timely treatment should be carried out in accordance with the doctor’s instructions to avoid further progression of the disease.