Colon cancer invading subplasma adipose tissue is severe. Colon cancer is a malignant tumor of epithelial origin of the colon, so it is more serious. If colon cancer invades into subplasma adipose tissue without lymph node metastasis and distant metastasis, it is stage II; if local lymph node metastasis occurs without distant metastasis, it is stage III; if distant metastasis occurs, it is stage IV. When colon cancer invades subplasma adipose tissue, it is necessary to clarify the pathological stage and carry out regular treatment. Surgery is an important treatment for colon cancer, such as radical resection surgery and palliative surgery. Targeted drugs can effectively inhibit cell proliferation and metastasis (e.g. cetuximab, bevacizumab, etc.). It can also be supplemented with chemotherapy (e.g. 5-FU, furacil, etc.) and radiotherapy. Therefore, colon cancer patients should actively accept the doctor’s treatment so as not to delay the disease.