The appearance of internal and external genitalia and secondary sexual characteristics in boys after the age of nine is called early symptoms. They generally refer to enlarged testicles and penis, appearance of pubic hair, muscle development, and thickening of the voice. Both males and females have accelerated growth and accelerated bone maturation, which can eventually lead to a lifetime height below the target height. In the presence of central nervous system lesions such as intracranial tumors, there may be headaches, vomiting, vision changes or other neurological signs and symptoms. x-ray, after taking bone films and checking bone age, there is an overdrive of bone age compared to age.