Proestrene Vaginal Gel Pills belong to the estrogen group of drugs, the use of which should be noted for people with estrogen-dependent diseases (such as breast cancer, uterine fibroids, etc.) is contraindicated. Prostacyclin Vaginal Pellets is a topical medication that can be used for conditions such as vaginal dryness caused by estrogen deficiency, and can relieve vaginal discomfort in postmenopausal women. The adverse effects of this medication are unclear, and although no systemic estrogenic effects of this medication have been detected in research studies, it is not recommended to be used in patients with estrogen-dependent tumors, such as breast cancer, uterine fibroids, and so on. Care should also be taken not to over-cleanse when using this medication. If symptoms such as vaginal dryness exist in post-menopausal women, they need to seek medical attention and be treated accordingly under the guidance of a doctor.