Taking anti-tuberculosis drugs for more than 20 days at night itchy skin pimples, consider the possibility of allergic dermatitis, it is recommended to the local hospital for a definitive diagnosis. Itchy skin at night after taking anti-tuberculosis drugs for more than 20 days may be caused by anti-tuberculosis drug-induced allergic (drug-induced) dermatitis, which should be treated with anti-allergy therapy in a specialized hospital, and ask the doctor to assess whether the medication needs to be adjusted, or stopped for observation. Allergic (non-pharmacological) dermatitis may also be caused by other allergens (e.g. pollen, dust, etc.), and should be treated with anti-allergic drugs such as chlorpheniramine in a hospital after a clear diagnosis. The medication should be rationally applied according to the doctor’s prescription.