The screening rate of Down’s syndrome screening is only about 60%, so when the results of Down’s syndrome screening are critical or high risk, most of them will be fine after further examination by non-invasive DNA or amniocentesis. Therefore, when there is an abnormality in the Down’s syndrome screening, pregnant women do not need to be overly nervous, but they must see a professional obstetrician and have non-invasive DNA screening or amniocentesis to confirm the diagnosis according to the doctor’s recommendation. If the pregnant woman is less than 35 years old and the result of Down’s syndrome is critical risk or high risk but the risk value is less than 1 in 50, she can undergo a review of non-invasive DNA. When the pregnant woman is older than 35 years old and the result of Down’s syndrome is high risk, especially if the risk value is more than one in fifty, non-invasive DNA review is not allowed, only amniocentesis can be performed. Therefore, when the results of Down’s syndrome screening are abnormal, you should consult a professional physician in a timely manner.