Redness, swelling and pain in the toes are common in the acute phase of gout attacks, especially after alcohol consumption. In addition, some patients, especially those with malignant tumors, are prone to gout attacks during intravenous chemotherapy, which can be characterized by significant local pain and even fever. If the condition allows, non-steroidal anti-inflammatory drugs can be administered, such as oral nimesulide dispersible tablets or intramuscular lysergic acid. Infectious diseases are also common in patients with diabetes mellitus, and local soft tissue contusions and trauma can lead to secondary infections. In patients with atherosclerotic occlusive disease, the ischemia of the distal limb may also lead to significant local soft tissue bruising and secondary infection, and the patient may experience significant pain, fever, and localized congestion and redness on examination.