If you have tooth pain, no matter what toothpaste you use, you need to visit a hospital for a specialist examination to determine the cause and treat the problem. Tooth pain may be caused by pulpitis or periapical inflammation, which requires a visit to the hospital for endodontic treatment. The best clinical treatment for pulpitis and periapical infection is root canal therapy, which can effectively relieve pain, remove inflammation, and permanently fill the root canal to prevent recurrence, or if there is a periapical abscess, it may require incision and drainage. Another possibility for tooth pain is wisdom tooth pericoronitis, which requires hospital consultation, pericoronial rinsing, local medication, and a combination of antibiotics, such as oral cephalosporin, penicillin, and metronidazole, etc. After the inflammation is relieved, the wisdom tooth should be extracted to prevent the recurrence of wisdom tooth pericoronitis.