The formation and development of liver fibrosis is the result of multifactorial and multi-linked synthesis, so the diagnosis of liver fibrosis needs to be confirmed by the following tests: 1. Biochemical tests: serum HA (hyaluronic acid), LN (laminin), PCIII (type III procollagen), and IV-C (type IV collagen), these four indicators can accurately reflect the degree of liver fibrosis, especially HA and PCIII have the highest diagnostic value for early liver fibrosis The highest; 2, imaging examination: ultrasound has good correlation with liver fibrosis stage for five parameters: liver surface, liver echo, hepatic vein, liver margin and spleen volume, but it is difficult to distinguish between stages 1-3; color Doppler ultrasonography or radionuclide scan can determine the blood flow and functional portal shunt of liver artery and portal vein; 3, liver biopsy pathology examination: this examination is the diagnosis of liver Fibrosis: this examination is the gold standard for the diagnosis of liver fibrosis and is an important basis for making a clear diagnosis, measuring the activity of inflammation, the degree of fibrosis and determining the efficacy of drugs.