Both high creatinine and uric acid are not necessarily due to kidney failure, but may also be caused by other diseases such as glomerulonephritis, diabetic nephropathy, gouty kidneys and so on. Both creatinine and uric acid are metabolic wastes, uric acid is purine metabolic waste and creatinine is metabolic waste produced by muscle tissue. Most of the elevated creatinine and uric acid are related to the kidneys. When creatinine and uric acid are elevated at the same time, it is mostly suggestive of decreased glomerular filtration rate, renal insufficiency and so on, but not necessarily renal failure, it may be other diseases such as chronic glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, polycystic kidneys, gouty kidneys and so on. Abnormal elevation of creatinine and uric acid, usually need to be combined with the patient’s condition and symptoms, further examination of renal ultrasound, urine routine, urine protein quantification, blood routine, etc., and if necessary, need to be through the renal puncture to clarify the specific type of disease. If patients find that both creatinine and uric acid are high, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.