Which material to use for skull repair is a question that patients with cranial defects are eager to understand. The commonly used material on the market is titanium mesh, which is also called synthetic titanium mesh. Although this material is widely used and is more advanced than some other traditional materials, it is not the ideal repair material for skull defects. Because titanium mesh is a metallic material, patients are prone to sensitivity to hot and cold stimulation after surgery, fluid is easily generated or stored in the subcutaneous tissues to be easily infected, and local discomfort or chronic pain may occur in the lesion. For example, the appearance of special areas such as temporal fossa and brow frame is not good after repair. If the repair is done with metal titanium plate, there may be radiofrequency effect when doing MRI, it will localize fever or burn the surrounding tissues. Titanium mesh is sensitive to heat and cold after cranial repair, with chronic local pain and more subcutaneous fluid; after repair, it affects patients to receive CT, MRI and other medical examinations; chronic cutting ulcers and stress perforation cause cranial repair failure; irregular facial and cranial parts such as temporal fossa, zygomatic arch and eyebrow frame have poor cosmetic appearance and so on. PEEK material is a bionic bone, which can be customized in three dimensions according to the degree of skull defect and precisely implanted in the defect area, which is a good choice material for patients with skull defect.