The increase in spots caused by rubbing retinoic acid cream on the face may be due to daytime use and lack of sun protection; or it may not be related to the use of the medication, but may be caused by your own pigmentation disorders such as freckles, melasma, and so on. Vitamin A cream is a keratolytic agent that can be used to treat conditions such as acne vulgaris, flat warts, and keratosis pilaris. If the patient does not take proper measures to avoid light during the use of retinoic acid cream, it may lead to hyperpigmentation and the appearance of more spots. In addition, if the face itself has freckles, chloasma and other diseases, may be affected by external factors such as ultraviolet radiation, or internal factors such as endocrine changes and so on, and skin lesions increased, and these factors caused by more spots and retinoic acid soft cream has no clear correlation. Topical application of such drugs can cause skin irritation symptoms, such as erythema, flaking and other adverse reactions. The use of retinoic acid cream needs to be contraindicated in people such as pregnant and lactating women, and people with allergies.