A common cause of painful and itchy symptoms in the palm of the hand is localized sensory nerves in the palm of the hand that are subjected to tension pulling and localized inflammatory stimuli, resulting in painful and itchy symptoms. Tension pulling often causes pain in the nerve, and localized inflammatory stimulation produces localized itchy symptoms, so both symptoms appear together, and localized swelling and inflammation are considered. Common causes include localized swelling and pain after an acute injury, and when the swelling gradually dissipates, inflammation still exists, and corresponding pain and itching symptoms can occur. In addition, localized arthritis will also lead to the appearance of the corresponding pulling and inflammatory stimulation symptoms, the appearance of pain and itching symptoms in parallel. Blood reperfusion after frostbite in the patient’s hands can also lead to pulling irritation as well as inflammatory stimulation and reperfusion stimulation, resulting in pain and itching at the same time.