Primary cholestatic cholangitis refers to primary biliary cholangitis, which needs to be treated by medication and general measures. 1. Drug therapy: patients need to follow the doctor’s instructions as soon as possible to apply ursodeoxycholic acid, which is a choleretic drug, can increase the secretion of bile acids, protect the bile duct cells and hepatocytes, and to a certain extent can slow down the development of the disease. Secondly, some patients also need to follow the doctor’s instructions to apply glucocorticoids, such as budesonide, dexamethasone, etc., or fenofibrate, obeticholic acid and other lipid-lowering drugs, which can help to improve liver function. 2. General measures: patients usually need to strengthen the intake of nutrients, reasonable combination of meals, adjust the dietary structure, eat more food rich in vitamins and calcium. Also pay attention to rest and keep the mouth clean. In most cases, the prognosis of primary biliary cholangitis is good if the patient cooperates with the doctor to carry out standardized treatment in time and strengthens the management of daily life, and the patient needs to follow up the consultation on time, so that the doctor can understand the changes of the condition.