Chlorpyrifos is a moderately toxic organophosphorus pesticide, the pathway of which is often seen as a result of accidental ingestion, or suicide by swallowing. The main mechanism of poisoning is that the drug can inhibit the activity of acetylcholinesterase, which in turn can cause the accumulation of acetylcholine, resulting in the corresponding clinical symptoms. For example, the patient may experience foaming at the mouth, muscle twitching, coma and other related symptoms. The first step in clinical treatment is to induce vomiting, gastric lavage and catheterization. At the same time, adsorbents such as activated charcoal can be placed in the gastrointestinal tract to reduce the further absorption of toxins and to accelerate the metabolism and excretion of toxins. The patient should be given cholinesterase resuscitating drugs such as desipramine and chlorophosphamide as soon as possible, and atropine may be given depending on the patient’s condition to achieve a synergistic treatment. In addition to the above treatment, patients should be given appropriate rehydration and diuretic treatment, and if necessary, blood purification treatment can be given to achieve rapid removal of toxins. During the treatment, the patient’s internal environment should be actively stabilized, acid-base imbalance and ionic disorders should be corrected, and the corresponding organ functions should be protected and supported.