It is a traditional medicine of the Miao ethnic group. The whole herb is used in folk medicine, which is warm in nature and sweet in taste, non-toxic, and has the effects of clearing heat and detoxifying, reducing yellow and dampness, activating blood circulation and removing blood stasis, and promoting water retention and swelling. Its main effects in the treatment of liver diseases include reducing liver damage, affecting bile secretion, and anti-Hepatitis B virus. This herb has been used locally for many years to treat jaundice, edema, amenorrhea, hematochezia, dysbiosis, bruises and injuries, as well as various types of hepatitis, cholecystitis, fatty liver, etc. Modern pharmacological research on the mechanism of action of Herba Epimedium in the treatment of liver disease may be through promoting the operation of the body bilirubin and bile acid excretion, and accelerate the efficacy of hepatotoxic drugs out of the body, in order to play a de-yellowing and detoxification effect. At present, there is still experimental research and clinical exploration on the treatment of liver disease by Herba Epimedium, and we hope it can make a breakthrough in the treatment of liver disease. Patients with liver disease are still recommended to go to the hospital for standardized treatment, which may be more symptomatic and effective for the cause or symptomatic supportive treatment.