Trigeminal nerve includes ophthalmic branch, maxillary branch and mandibular branch. Trigeminal neuralgia is most common in the maxillary and mandibular branches, and its innervating parts include the teeth and gums of the upper jaw and the teeth and gums of the lower jaw, so trigeminal neuralgia patients will have toothache when they suffer from an attack, that is, trigeminal neuralgia toothache is the manifestation form of trigeminal neuralgia. Trigeminal neuralgia is more common in adults and the elderly, more women than men, the onset of the attack manifested as severe electric shock-like, needle-like, knife-like or tear-like pain, lasting a few seconds or 1-2 minutes, sudden sudden stop, the interval is completely normal. Its etiology is still unknown, some scholars believe that the lesion is located in the trigeminal nerve semilunar node to the interbranchial portion of the brain, due to a variety of causes of compression; some other scholars believe that trigeminal neuralgia is a kind of sensory epileptic seizures, abnormal discharge site may be in the trigeminal spinal tract nucleus or the brainstem. The pathogenesis of trigeminal neuralgia is still being explored, and many scholars believe that it is caused by various reasons, such as local demyelination of the trigeminal nerve to produce abnormal impulses, the formation of pseudo-synapses in neighboring nerve fibers or short circuits, and the transmission of minor nociceptive stimuli into the center through short circuits, and the transmission of impulses from the center through short circuits, which are superimposed on each other and lead to the trigeminal neuralgia seizures. In summary, trigeminal neuralgia toothache is one of the manifestations of trigeminal neuralgia, which may be a transient recurrent severe pain associated with microvascular compression of the trigeminal nerve root leading to nerve demyelination, and should be treated under the guidance of a professional neurologist.