Prickly heat on the hands should keep the skin dry and clean, and follow the doctor’s instructions to use topical and oral medication. Prickly heat is a kind of skin disease that is easy to occur in a hot and humid environment. If you have prickly heat on your hands, you should keep your hands cool, clean and dry, and avoid scratching the skin at the prickly heat area with your hands to avoid secondary infection. Topical glycerin lotion, prickly heat powder, or glucocorticoid drugs such as mometasone furoate gel can be used to relieve symptoms. If the local skin is scratched and broken, secondary infection, mupirocin ointment and other drugs can be used; in addition, oral loratadine and other drugs can also be taken to relieve the symptoms of itching. If the patient’s hands prickly heat, need to follow the doctor’s advice to use medication.