Ibuprofen should be taken again only after an interval of at least 4-6 hours. Ibuprofen is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects, which is mainly used clinically for the treatment of various moderate or mild pains, such as headache, joint pain, toothache and muscle pain, and also for the treatment of fever caused by cold. Ibuprofen has more serious gastrointestinal irritation, which can induce gastric ulcer, gastric bleeding and even lead to perforation of the stomach, so ibuprofen should not be taken in large doses for a long time. For patients with persistent pain or fever, it should be taken again at least 4-6 hours apart, but not more than 4 times in a 24-hour period. Ibuprofen is an allopathic medicine, which can only relieve symptoms and should not be used in large quantities for a long time. If the pain is still not relieved after 5 days of continuous use, or if fever still appears after 3 days of continuous use, you should go to the hospital immediately.