Gentamicin allergy may lead to deafness. Gentamicin is a relatively common antibiotic that is mainly used to treat diseases associated with acute bacterial infections. If a patient is allergic to gentamicin, the patient is relatively more sensitive to this drug and the chances of causing deafness are higher. There is also a possibility of causing other symptoms such as tinnitus, vertigo, nausea and vomiting. There are individual differences in the degree of hearing loss caused, with some patients experiencing mild, some moderate, and a small percentage of patients experiencing severe. If deafness occurs, it is necessary to stop the medication as soon as possible, as soon as possible to the otorhinolaryngology department, need to do audiological testing to clarify the degree of hearing loss. Targeted medication is also needed, which can be combined with hyperbaric oxygen at the same time, which also has an adjunctive therapeutic effect.