The n-terminal natriuretic peptide precursor shall be called N-terminal B-type natriuretic peptideogen (NT-proBNP) and is a commonly used indicator of cardiac function tests. NT-proBNP is associated with B-type natriuretic peptide (BNP), both generated by cleavage of B-type natriuretic peptide proteins produced by transcription of the BNP gene, and together they serve as an important clinical test in cardiac insufficiency. Under physiological conditions, a small amount of BNP/NT-proBNP can be detected in circulating blood; when cardiac load is increased or ventricles are enlarged, cardiomyocytes are stretched and synthesize and release BNP/NT-proBNP into the bloodstream, and the plasma BNP/NT-proBNP level is elevated and correlates significantly with cardiac function grading. It is important to note that NT-proBNP has a longer half-life, higher stability, and higher sensitivity than BNP, and is better able to respond to activation of the BNP pathway, which makes it easier for clinicians to accurately detect early and mild heart failure. Patients with elevated NT-proBNP are advised to seek prompt medical attention to identify the cause of their condition.