Cranial repair is the process of taking surgical methods to artificially plasticize and repair the defective cranium after the cranial defect caused by various reasons in life. The main role of cranial bone repair is to protect the soft tissues of the brain, eliminate the psychological shadow caused by cranial defects, and restore the normal state of brain tissues, so as to improve the quality of life of patients. The main cause of cranial bone repair is cranial defects caused by craniocerebral trauma and intracranial diseases and other craniotomies. If there are symptoms such as intracranial infection, hydrocephalus, and brain swelling at the site of injury, cranial bone repair can be delayed to prevent infection after autologous or allogeneic implantation. We choose the new PEEK material for cranial bone repair, because PEEK material (polyether ether ketone) belongs to the semi-crystalline thermoplastic material, which is resistant to high temperature, chemical resistance, fatigue resistance, with excellent strength hardness and toughness, it is a more ideal material for cranial bone repair. Through a large number of basic research and clinical use of PEEK materials. And it has been proved that the use of polyether ether ketone as a material for repairing the skull will not have the various complications, sensitivity to hot and cold reactions, subcutaneous fluid accumulation and other problems that may occur with other traditional materials. Moreover, the PEEK material is 3D printed to accurately match the defective area, restoring the original craniomaxillofacial appearance and meeting the requirements for aesthetics. The cost of craniofacial repair has a close relationship with the material used for the repair, good material repair effect is better, and the postoperative recovery is also better, the cost may also be slightly higher. At present, a few regular hospitals have chosen PEEK material for cranial bone repair, which can achieve very ideal results.