If women around 40 years old want to prepare for pregnancy, they not only have to consider the risk of advanced age, but also have to face the age and physiological, psychological and social factors and other aspects of assessment. Therefore, it is very important to know how much the couple is thirsty for a second child before preparing for pregnancy, if there is more than 80%, do a good basic pregnancy preparation check and grab the time to work hard, each individual situation is different, others’ are just cases, their own is life. Other people’s failures are not necessarily your situation, and other people’s successes may only be an incentive. The best and most powerful doctors can not tell you whether you can get pregnant and have a healthy and smart baby without trying and doing it, you can only do and try, and pregnant and cherished. If the desire is not 50% and the woman is over 45 years old, then please let go of your obsession and raise the oldest one well, or wait for the oldest one to give you a grandchild, which is also a kind of heavenly joy. In short, the preparation of mind and determination before preparing for the second pregnancy at an advanced age is more important than the mere medical problems.