Dry syndrome may increase the frequency of bowel movements after taking medication, which is generally considered to be an adverse reaction to the medication. Dry syndrome has an insidious onset and diverse clinical manifestations, mainly related to the impairment of the function of exocrine glands such as salivary glands and lacrimal glands. Symptoms of the disease are dry keratoconjunctivitis, dry mouth, purpura-like rash on the skin, joint pain and so on. Patients taking medications may experience diarrhea or multiple bowel movements, suggesting that it is related to the medication used, such as hydroxychloroquine, which can be discontinued for active observation and the treatment regimen can be adjusted appropriately. As far as the patient’s immune system is concerned, dry syndrome is mainly caused by autoimmune abnormalities, and prolonged dehydration and dryness of the skin can also lead to dry syndrome. In the absence of digestive disorders, keeping the body organs, the skin, and other tissues moist can be effectively prevented by drinking more water, increasing the water content of blood vessels, and reducing or avoiding the use of chemical substances. If the patient’s symptoms of dry syndrome are severe, or if the symptoms persist and do not improve, he or she should go to the hospital in time for treatment and should not use medication on his or her own.