Epiglottis ulcers are often acute inflammation, but may also be malignant lesions, long lasting epiglottis ulcers need biopsy for clear diagnosis. Epiglottis ulcer is related to bad life habits, such as like to eat spicy, stimulating food, or diet too hot, too fast, etc. will cause damage to the epiglottis mucosa, the formation of ulcers, the emergence of sore throat, foreign body sensation and other inflammatory symptoms. If it is not effectively controlled for a long time, there is a possibility of cancerous transformation, or it is already early epiglottis cancer. If the pathological examination result is inflammatory lesion, attention should be paid to improve the lifestyle, avoid spicy and stimulating food, avoid too hot food, eat more fruits and vegetables, and can use watermelon cream tablets and furacillin gargle under the guidance of doctor. If the result of pathological examination is malignant, such as squamous cell carcinoma, adenocarcinoma, etc., it is necessary to give surgical treatment in time, or combined with comprehensive treatment such as radiotherapy and chemotherapy. It is suggested that patients should actively consult doctors for systematic examination, and follow the doctor’s instructions to standardize the medication and treatment after clarifying the cause of the disease.