Large blisters on the soles of the feet are generally friction blisters, caused by excessive exercise or repeated friction, and usually grow on the soles of the feet, palms of the hands and other areas with a thicker stratum corneum. The large blisters on the soles of the feet need proper rest, and keep the skin clean and hygienic, and if necessary, give medication, and strengthen the local care. 1. Appropriate rest: large blisters on the soles of the feet, patients should pay attention to rest, avoid strenuous exercise, walking, in order to reduce repeated friction, aggravate the symptoms of pain. 2. Keep the skin clean: large blisters on the soles of the feet, the tissue fluid in the blisters can generally be gradually absorbed without special treatment, but if the thick-walled large blisters, the doctor can use a sterile syringe to draw out the local tissue fluid, so that the walls of the blisters are attached to the skin, and gradually healed. 3. Medication: After the blister breaks on its own or the tissue fluid is withdrawn, it should be sterilized with iodine povidone, and mupirocin ointment can also be applied locally to prevent bacterial infection. 4. Enhanced care: patients with large blisters on the soles of their feet, or those with diabetes, who have difficulty in healing wounds, can use physical therapy such as red light irradiation to keep the blisters clean and dry, thus promoting wound healing and reducing pain. Large blisters on the soles of the feet, the patient should consult a doctor in a timely manner, and follow the doctor’s instructions to standardize the treatment, not to cut the skin lesions on their own, so as not to cause pain and infection.