The most common cause of a pit on the leg when pressed is due to renal insufficiency, cardiac insufficiency and hypoalbuminemia. Patients should be advised to further check renal function, cardiac ultrasound, BNP, liver function, etc. If it is triggered by hypoalbuminemia, supplemental albumin should be taken accordingly, and the situation will gradually improve when the albumin is corrected. If it is caused by renal insufficiency or heart failure, it should be combined with diuretic treatment, and the commonly used diuretic is furosemide. Oral tolvaptan is also an option if the patient has severe edema of the lower extremities along with hyponatremia. For patients with hypoalbuminemia, in addition to albumin supplementation, a high-quality protein diet should be observed on weekdays. If it is caused by renal insufficiency, it is also necessary to combine it with hemodialysis if necessary, or to monitor it during the medication. If the urine output is excessive, it is important to supplement potassium or sodium ions in a timely manner.