1, prescription saline 100ml + omeprazole 40mg + vitamin B60.3 Result: the infusion gradually turned yellow and finally black. Analysis: The pairing of omeprazole and vitamin B6 has not been reported in the literature and is not described in the instructions. Omeprazole is an alkaline drug, can raise the pH value of saline, vitamin B6, also known as pyridoxine hydrochloride, containing phenolic hydroxyl group, PH value of 3 ~ 4, the two role in the occurrence of acid-base neutralization, the discoloration may be the phenolic hydroxyl of vitamin B6 in the alkaline conditions of the oxidized cause, so the two should not be in the same bottle of infusion with. 2.Prescription: 25% glucose 40ml+10% calcium gluconate+dexamethasone 5mg Result: generation of insoluble calcium salt precipitation. Analysis: Calcium gluconate is forbidden to be paired with oxidizing agents, citrates, soluble carbonates, phosphates and sulfates, generating insoluble calcium precipitates (Calcium gluconate instruction manual), which is life-threatening. So the two should be injected separately intravenously. 3, prescription: mannitol 250ml + dexamethasone 5mg. Result: possible precipitation of crystallization of mannitol phenomenon. Analysis: Mannitol is a tissue dehydrating drug, dexamethasone has anti-inflammatory effect, the two matching is conducive to the elimination of edema. Because 20% mannitol for supersaturated solution, the joint application of other drugs, may be due to new solutes and solvents added to change the solubility of mannitol and precipitation of mannitol crystals. Therefore, the two should be used separately, and should not be added to the same container for use. 4, Prescription: 25% glucose 40ml + cediran 0.4mg + furosemide 20mg. Intravenous injection Result: Generation of furazanilic acid precipitation Analysis: furosemide is a weak acid and strong alkali salts, PH 8.5-10, prohibited and acidic liquid with the acidic environment, in the acidic environment (2% glucose PH3.5-5) generation of furazanilic acid precipitation, endangering the life. It can be 25% dextrose + cediran, NS + furosemide, separate intravenous injection. Furosemide instructions state that furosemide is diluted with saline, not with glucose. Allergy to sulfonamides is prohibited. 5, Prescription: glucose 250ml + vitamin K1 injection 40mg + vitamin C 3.0g Result: redox reaction between the two, so that the efficacy of vitamin K1 reduced. Analysis: Vitamin C has strong reducing properties, and quinone drug vitamin K1 mixed, can occur redox reaction, and make vitamin K1 efficacy is reduced. Vitamin K1 injection and vitamin C injection placed for a period of time, vitamin K1 was completely destroyed. 6, prescription: cimetidine injection combined with aminoglycoside antibiotics; cimetidine injection combined with clindamycin. Result: respiratory depression. Analysis: cimetidine, aminoglycoside antibiotics, clindamycin can be combined with the calcium binding site on the presynaptic membrane at the neuromuscular junction, and block the release of acetylcholine, resulting in neuromuscular junction blockade. The combined application of the neuromuscular junction blocking effect is strengthened, may cause respiratory depression, life-threatening, therefore, must pay attention to the combined use. Once respiratory depression occurs, calcium chloride should be injected immediately to counteract it. In addition, the combination of this drug and anesthetics, easy to cause respiratory muscle paralysis, clinical application should also pay attention to. For adverse effects and contraindications of cimetidine, please refer to the drug insert. 7, Prescription:3:2:1 injection 500ml + phenol sulfoethylamine injection 0.25sigivgtt Result: the color of the solution turns red after a few minutes. Analysis: Phenol sulfoethylamine can enhance platelet function and platelet adhesion, shorten coagulation time, and can reduce capillary permeability and prevent blood osmosis.3:2:1 solution contains sodium bicarbonate 34ml, the solution is alkaline, and phenol sulfoethylamine, due to phenol sulfoethylamine contains phenol hydroxyl, and alkaline drugs with easy oxidation and discoloration, discoloration point of PH is 6.7, therefore, the two drugs are easy to be combined to the phenol sulfoethylamine discoloration. Therefore, the combination of the two drugs will easily lead to the discoloration of phenolsulfone ethylamine. 8, Prescription: 5% glucose injection + adenosine triphosphate 20mg + coenzyme A injection 100u + vitamin B6100mg Result: after mixing to produce precipitation. Analysis: commonly used ATP-2Na, stable in PH8 ~ 11, when acidic, then produce precipitation, vitamin B6 is water-soluble pyridoxine hydrochloride, PH 3 ~ 4, can make ATP-2Na produce precipitation. Therefore, avoid static drip in the same container. 9, Prescription: 0.9% sodium chloride injection 100ml + Flurofloxacin injection 0.2sigivgtt Result: a few minutes after the solution to form a white mixed candle precipitation. Analysis: Flurofloxacin injection instructions in the [precautions] in the clear provisions: “Avoid and sodium chloride injection or glucose sodium chloride injection combined. Floxacin injection and 0.% sodium chloride injection can generate a white precipitate, precipitate Floxacin. Fleroxacin Injection is made by utilizing the structure of fleroxacin with both acidic and basic groups, which can generate soluble salts with amino acids, and the solubility is reduced in electrolyte solution due to the homoionic effect, resulting in the formation of particles coalescing in a short period of time to produce a precipitate. In addition, Fleroxacin is a fluoroquinolone, which contains the basic structure of quinoline ring skeleton and 3 fluorine atoms, and the combination of this structure with chlorine ions will result in an integration reaction, generating a large-molecule integrative precipitate, affecting the content of the drug and weakening the therapeutic effect. When used clinically, Flurofloxacin Injection should never be paired with injections containing sodium chloride. That is, avoid combining with sodium chloride injection or glucose sodium chloride injection. This product should also not be mixed with other drugs. It should be diluted in 5% dextrose 250-500 ml of injection solution when preparing infusion solution, and then slowly injected intravenously, avoiding light, 0.2-0.4g once, once a day. The intravenous drip speed should not be too fast, every 0.2g drip time of at least 45 ~ 60min Fleroxacin in addition to the influence of chloride ions, temperature, light also has a certain effect. Fleroxacin and 5% GS injection, sunlight exposure after 20 minutes, the original colorless clarified liquid becomes lavender, so fleroxacin injection should be stored away from light.