The time between the detection of symptoms and the definitive diagnosis of amyotrophic lateral sclerosis is usually 1 year. Amyotrophic lateral sclerosis, also known as acromegaly, is a disease of the motor nervous system. The cause of this disease is unknown and is generally believed to be a genetic basis of oxidative damage and excitotoxic effects that damage motor neurons. The common clinical manifestations of acromegaly are myasthenia gravis, muscle weakness, and fascicular fibrillation. Tests for amyotrophic lateral sclerosis include blood tests, cerebrospinal fluid tests, electromyography, and motor evoked potentials, and the time from the detection of symptoms to a definitive diagnosis is usually about 1 year. Amyotrophic lateral sclerosis remains an incurable disease, but a variety of methods such as symptomatic and etiologic treatments are available to improve clinical outcomes and quality of life for patients. It is recommended that when amyotrophic lateral sclerosis is suspected, the patient should go to a professional neurologist in a timely manner for electromyography, imaging and other auxiliary differential diagnosis, and then follow the doctor’s instructions for standardized treatment after the diagnosis is confirmed.