The appearance of hand and foot syndrome after taking Anrotinib is generally based on the severity of the hand and foot syndrome to decide whether to discontinue Anrotinib, while timely administration of topical emollients, hormonal ointment, the use of analgesic drugs such as celecoxib, or the use of antibiotic treatment, if necessary. The hand-foot syndrome that occurs after taking Anrotinib is clinically categorized into three levels, depending on the manifestation of skin symptoms. Grade I hand-foot syndrome can be treated by continuing to take erlotinib and giving topical emollient cream, or hormonal ointment such as mometasone, to the skin lesion area. Grade II hand-foot syndrome can also continue to apply anrotinib, some patients can be appropriate to reduce the dose, the use of emollient cream or hormone ointment at the same time, you can use celecoxib and other anti-inflammatory analgesic drugs for treatment. Tertiary hand-foot syndrome, generally need to stop the use of Anrotinib, in the use of the above treatment, some patients need to add antibiotics for treatment.