1. Abnormal lumps: lumps in superficial areas that do not disappear or increase in size over time. Such as breast, neck, skin. 2.Mole enlargement, enlargement, hair loss, ulceration, deepening of color. 3.Abnormal sensation: discomfort, pain, etc. 4.Ulcerated soup does not heal: skin, mucous membrane. 5.Persistent indigestion and loss of appetite, emaciation, anemia. 6.Change in stool habit, alternating constipation and diarrhea, mucus and blood stool. 7, persistent hoarseness, dry cough, blood in sputum. 8.Tinnitus, hearing loss, epistaxis, blood in secretion, headache. 9.Irregular vaginal bleeding outside the menstrual period or after menopause. 10.Hematuria, dyspareunia. 11, Unexplained progressive weight loss.