Fenmadone is a combination preparation of Estradiol Tablets/Estradiol Dydrogesterone Tablets. Brown discharge may occur if the combination preparation of Estradiol Tablets/Estradiol Dydrogesterone Tablets is not consumed. The combination preparation of Estradiol Tablets/Estradiol Dydrogesterone Tablets is mainly used for the treatment of perimenopausal syndrome caused by natural or postoperative menopause. A small amount of brown discharge while taking the combination preparation of Estradiol Tablets/Estradiol Dydrogesterone Tablets may be the result of a small amount of vaginal bleeding, which was not discharged in time and was oxidized and formed in the vagina. The combination preparation of Estradiol Tablets/Estradiol Deferiprone Tablets may cause headache, nausea, vomiting and other adverse reactions; it is contraindicated in the presence of known or suspected breast cancer, progesterone-dependent tumors, unexplained genital tract bleeding, active thrombosis, acute liver disease or impaired liver function. If the bleeding symptoms are not relieved, or accompanied by other symptoms, should promptly go to the hospital for consultation, to identify the cause and then give targeted treatment.