Hepatitis B two pairs of half – surface antigen (HBsAg) positive, e antigen (HBeAg) positive, core antibody (HBcAb) positive. Commonly known as Hepatitis B Major Triple Yang, it means that the Hepatitis B two-to-one test is positive for surface antigen (HBsAg), e antigen (HBeAg) and core antibody (HBcAb). Major triple-positive means that the virus is replicating heavily in the body and is highly contagious. The reason for this is that the autoimmune function is low and there is no ability to fight against the hepatitis B virus resulting in a large amount of hepatitis B virus replication in the body. Therefore, it is necessary to pay attention to personal hygiene to prevent infecting relatives and friends in the vicinity, and to have regular checkups to prevent the toxins released by the massive replication of the hepatitis B virus from causing related pathologies, such as elevated transaminases, enlarged liver and spleen, and biliary cirrhosis due to poor detoxification of the liver. The principle of treatment of hepatitis B: If the liver function of hepatitis B is normal, there are no clinical symptoms, and no obvious damage to the liver is seen in the various tests. Such patients with hepatitis B major triple-positive should be dynamically observed, with HBV serology and biochemical indexes of liver function and ultrasound testing every 3-6 months, and should avoid alcohol consumption and overexertion in life. For patients with abnormal liver function, DNA test greater than the normal value of HBV-DNA, clinical symptoms of hepatitis B, suggesting the active stage of chronic hepatitis B, they need to receive antiviral treatment in hospital in time, the principle of treatment is to make the liver function of hepatitis B gradually balanced, hepatitis B virus replication index gradually negative. In particular, it should be noted that patients with hepatitis B major triplets who are older than 40 years old need to be treated in a timely manner, regardless of whether their liver function is normal or not. The principles of treatment are different for different periods of hepatitis B. Patients with hepatitis B major triple yang must follow the guidance of their doctors for scientific treatment based on scientific examination.