Recently, the Department of Hepatology saw a special hepatitis B major triple-positive patient, Ms. Zhang, 26 years old, who was found to have hepatitis B with high transaminases and a high HBV DNA viral load during her medical checkup in March 2008, and was hospitalized for one month, then was given interferon, and was converted to hepatitis B minor triple-positive with normal liver function and HBV DNA in June, until April 2009, when she started to stop the dry furin. At first, Ms. Zhang thought her condition was better, however, when she was rechecked last October, her transaminase was as high as 300 units and her HBV DNA viral load was elevated by more than 6 times, turning her into hepatitis B major triple-positive again, so Ms. Zhang was treated again for more than half a year, this time at another liver hospital, where she was hospitalized with transaminase of more than 300, DNA of 6 times, alpha-fetoprotein of more than 90, and ultrasound showing enhanced and thickened echogenicity The doctor said that the abdomen was distended. The receiving doctor thought that playing interferon was not good and easy to rebound, and formulated a liver-protecting and enzyme-lowering treatment plan for Ms. Zhang. During her hospitalization, she was given three IVs every day, the first two weeks: salvia, magnesium isoglycyrrhizate, and polyenyl phosphatidylcholine; the second two weeks: salvia, diammonium glycyrrhizate, and reduced glutathione. Then there are also oral medications: Pientzehuang, Yinbeiheping Liver Capsules and Enzyme Reducing Spirit. After one month’s treatment, the doctor said that the treatment effect was quite satisfactory, and the unexpected thing was that the alpha-fetoprotein rose to more than 800, and the doctor who received her at that time couldn’t explain it and suggested Ms. Zhang to do CT to check whether there was cancer. So, the panic-stricken Ms. Zhang questioned the hospital and doctors she had seen before. Ms. Zhang couldn’t help but complain that she had spent 10,000 yuan a month in the hospital, and the situation seemed to be getting worse. I really can’t believe those doctors. For Ms. Zhang’s question of whether elevated fetoprotein could be liver cancer? How should I treat hepatitis B major triple yang? Liver disease treatment experts explained that fetoprotein is an indicator of liver cancer. Generally speaking, if the absolute value of fetoprotein exceeds 400 and increases progressively, it is necessary to consider whether there is liver cancer. However, this is not absolute. Because AFP reflects the proliferation of liver cells, elevated AFP may be a malignant proliferation of liver cells. However, in another case, there is also a large proliferation of hepatocytes during inflammation, and this may also result in a significant increase in methemoglobin, but this is a benign proliferation. In this case, as the inflammation improves, the amount of methemoglobin will gradually decrease. Therefore, the key to the elevation of methemoglobin is to observe its changes dynamically. Of course, since liver cancer is mostly accompanied by imaging changes, ultrasound, CT or MRI are necessary for elevated methemoglobin. Some patients are discharged from the hospital with AFPs above 1000 and return to normal only after several months. Clinical situations are very different and any accident is possible. In Ms. Zhang’s case, elevated AFP is indeed unexpected, but it does not mean that the situation is getting worse, therefore, the work to be done is further examination and to develop a treatment plan for liver disease based on the results.