Patient: Description of the condition (main symptoms, onset time) since childhood is a virus patient, previously took a little liver protection drugs, can be turned negative? Li Xiaobo, Institute of Liver Diseases, Peking University Hospital: A complete cure for hepatitis B is currently unrealistic. For patients with active hepatitis B virus replication and active inflammation, long-term antiviral therapy is advocated to control the progression of inflammation and cirrhosis and to prevent and reduce complications. There are two main types of antiviral means, interferon and nucleoside analogues For patients with active hepatitis B virus replication, along with no active inflammation, follow-up observation and antiviral therapy can be given for those with cirrhotic tendency. For patients with inactive hepatitis B virus replication, along with no active inflammation, follow-up is sufficient.