Failure of sperm and egg to unite indicates that the woman is unable to conceive. The cause may be due to the presence of sperm antibodies in the female reproductive system, gynecological inflammation, or the inability of the female fallopian tubes. Depending on the cause, medication, artificial insemination, anti-inflammatory and surgical treatments can be used. 1. Women have anti-sperm antibodies: anti-sperm antibodies prevent sperm and egg from combining, and a few anti-sperm antibodies affect the division of the fertilized egg and its implantation. Women can use condoms to prevent sperm from entering the body and take glucocorticosteroids such as dexamethasone after 3 months before conception. 2. Vaginitis: If vaginal inflammation occurs, anti-bacterial antibodies may appear in a woman’s body. It will be unfavorable for the sperm to combine with the egg. It is usually treated with medication, such as trichomonas vaginitis, which can be treated with metronidazole. Moldy vaginitis, itraconazole and other drugs can be treated. 3. Tubal blockage: Blockage of the fallopian tubes can lead to sperm and egg not being able to combine. Generally, the clinic will carry out surgery to unblock the fallopian tube. Proximal blockage, usually using hysteroscopic surgery. For middle tubal blockage, laparoscopic surgery is usually used. If the sperm and egg do not combine, you need to seek medical treatment as soon as possible, do not use your own medicine to avoid causing adverse complications.