Ki67 indicator is very important, the corresponding antigen comes from proliferating cells, and is closely related to mitosis, which can determine the malignant degree of the tumor as well as the prognosis. Ki67 originates from proliferating cells in the process of mitosis and is expressed in S, G1, G2 and M phases of the cell cycle. The higher the corresponding index, the stronger the proliferative ability of the cells, the faster the mitotic division, the weaker the differentiation ability, the higher the relative malignant degree, and the more likely to recur and metastasize after surgery, which belongs to the important immunohistochemistry indexes, and the higher the value, the poorer the relative prognosis. Ki67 plays an important role in guiding clinical treatment, the overall need to be combined with the staging of the disease to make a comprehensive judgment, it is recommended to standardize the treatment under the guidance of clinicians.