The actual high bicarbonate generally reflects that the body is currently in metabolic alkalosis, which may be caused by overuse of alkaline medications, excessive salt corticosteroids, gastrointestinal disorders, and so on. 1. Excessive use of alkaline drugs: some patients will overuse alkaline drugs, such as sodium bicarbonate tablets, due to the relatively high acid content in the body, thus leading to high bicarbonate in the body. 2. Excessive hydrocorticotropic hormone: For example, renal artery stenosis, cortisolism, adrenal cortical hyperplasia and other diseases may lead to excessive secretion of hydrocorticotropic hormone, thus causing high bicarbonate. 3. Gastrointestinal diseases: for example, acute gastroenteritis, which often leads to frequent vomiting and diarrhea symptoms, resulting in high bicarbonate in the short term due to a large loss of body fluids. The actual high bicarbonate may also be caused by other reasons, such as furosemide and other diuretics used inappropriately, etc., the patient should consult the doctor in a timely manner to identify the cause of the problem, and then follow the doctor’s instructions for targeted treatment.