After taking ibuprofen for toothache in about half an hour to an hour, it will gradually take effect, and its concentration will reach its peak in about four hours, and then gradually decrease, and usually lose its effect in about eight hours. If the patient is suffering from acute dental nerve pain, conventional painkillers are not able to stop the pain, you need to go to the hospital in time to open the pulp drainage. For pain relief after tooth extraction or pain caused by chronic apical inflammation, taking ibuprofen or rosoprofen sodium can have a good pain relief effect. However, painkillers can cause some damage to the liver, so patients are advised not to overdose on painkillers because of too much pain, and to always follow the instructions. It is best to take half a tablet at first, if the pain relief effect is not good and then gradually increase the amount of normal circumstances can not be more than a piece, generally within eight hours can only eat a piece, to avoid excessive damage to the liver.