A 0.4-centimeter ground-glass nodule without any discomfort does not require special treatment and regular follow-up is sufficient. If there are symptoms such as unclear margins, burr sign and pleural invasion, surgical resection is required. 1. Cases that do not need treatment: If the ground glass nodule is not big and there are no symptoms such as burr sign and pleural invasion. No special treatment is needed. This small nodule is usually a common benign nodule. Without any clinical symptoms, it is recommended to have a regular review, usually pay more attention to diet, quit smoking and drinking, and have more rest. 2. Cases requiring treatment: If the edge of the ground-glass nodule is not clear, accompanied by burr sign and pleural invasion and other concomitant symptoms, in this case the ground-glass nodule has a higher risk and needs to be surgically removed as soon as possible. If the postoperative pathological findings are malignant, the nodule can be treated with chemotherapy and targeted therapy to increase the cure rate and prevent recurrence of tumor cells. In conclusion, when there is a 0.4 cm ground-glass nodule, whether it is necessary to deal with, we need to improve the corresponding examination in time to clarify the nature of the tumor, and follow the doctor’s instructions.