With the improvement of people’s living standards and the increasing aging of the population, the incidence of diabetes is also showing a significant increase. Diabetic foot lesion (diabetic foot) is one of the most common and serious complications of diabetes mellitus. It is a foot lesion specific to diabetes caused by peripheral neuropathy, vascular disease (mainly lower limb occlusive atherosclerosis), and infection. The main clinical manifestations are foot ulcers, infection and gangrene, which often bring great pain and heavy economic burden to patients, and the consequences can lead to amputation or even life-threatening. According to statistics, 15% of diabetic patients will develop diabetic foot, and 10%-15% of them will have their limbs amputated as a result, and the mortality rate of patients after amputation is quite high. In the past, it was generally believed that the vascular lesions of diabetic foot occurred in the tiny blood vessels at the end of the limb, and such peripheral vascular lesions could not be treated by surgical or endoluminal interventional procedures. In recent years, with the improvement of vascular diagnosis and treatment technology, it has been found that some diabetic patients have vascular lesions located in the arteries of the lower leg below the knee, and these vascular lesions have full opportunities to be treated by endovascular techniques or surgical bypass surgery. The main method of endoluminal minimally invasive treatment is to open and dilate the narrowed or occluded calf arteries with the application of micro-guide wires and micro-balloons, and if necessary, small diameter stents can also be placed. Of course, bypass surgery of the distal limb artery can also be performed if the conditions are suitable. Through these treatments, the arterial blood supply to the affected limb can be restored or improved to avoid or reduce the chance and extent of limb (or toe) necrosis, and to preserve as much limb shape and function as possible. In particular, minimally invasive endovenous treatment can be completed by puncture at the root of the thigh under local anesthesia, which has the advantages of being less invasive, easier to be tolerated by old and sick patients, and can be performed repeatedly. The key to achieving good treatment results for diabetic foot vasculopathy is early detection, early diagnosis and early treatment. The early symptoms of diabetic foot include coldness, numbness, white or purple skin, and dullness or loss of sensation. If the disease worsens, intermittent claudication can occur, which means that pain in the lower leg or foot occurs when walking, and it is necessary to stop and rest for a moment before continuing to walk. Later, the lower extremity may become painful even when resting, and even sleeplessness may occur, and then the toe may break down, become infected, and become necrotic. The best time for surgical treatment is before the onset of limb necrosis. Therefore, when some of the above early manifestations appear, patients should go to the hospital to see a vascular surgeon and do some corresponding examinations, and once a vascular lesion suitable for treatment is found, timely treatment can be carried out. Once necrosis of the limb has occurred, even if the blood vessels can be opened, the necrotic tissues cannot be revived and will inevitably result in the loss of part of the limb. In conclusion, for diabetic patients, in addition to active and effective blood glucose control, sufficient attention should be paid to diabetic complications such as lower limb vasculopathy. It is in the interest of the patient, the family and the society to seek timely medical attention and to seize the favorable treatment time to implement effective treatment, so as to reduce the rate of limb disability and death.