The aggravation of headache on the 8th day after craniotomy may be caused by increased intracranial pressure, nerve damage in the brain, as well as blood pressure fluctuation and infection. 1. Increased intracranial pressure: after craniotomy, increased intracranial pressure is the most common complication, due to postoperative hemorrhage may cause brain tissue edema, the dura mater and vascular nerves caused by compression and stimulation, there will be a headache on the 8th day after surgery. 2. Brain nerve damage: the process of craniotomy will lead to a certain degree of brain nerve damage, which will cause the symptoms of headache aggravation on the 8th day after craniotomy. 3. Blood pressure fluctuation: when the patient has nervousness, restlessness and other emotions, it may cause an increase in blood pressure, resulting in vascular throbbing headache on the 8th day after craniotomy. 4. The worsening of headache on the 8th day after craniotomy may also be due to intracranial infection, which requires timely anti-infection treatment. When patients experience worsening headache on the 8th day after craniotomy, it is recommended that they ask their doctor in time.