It is not scientific to say that the best method of estrogen supplementation is the best. Oral estrogen, transdermal absorbed estrogen and transvaginal injectable estrogen can be chosen according to the need, and the appropriate drug should be selected according to the actual situation of the individual. Oral estrogen has the advantages of easy to use, low price and good patient compliance. Currently, commonly used estrogens include estradiol valerate and 17-estradiol. There are also some artificial estrogens, such as hexestrol and ethinyl estradiol. However, they may also be a risk factor for blood clots, so they should be used with caution or prohibited in patients with severe obesity and estrogen-related tumors. Estradiol patch and estradiol gel are transdermal absorption estrogens. This is a better option for patients with dyslipidemia, diabetes, hypertension, and estrogen needs. Estrogen ointment, protoprene vaginal capsules, protoprene vaginal ointment, chloroquinaldoprene vaginal tablets, estriol ointment, etc. are vaginally injected estrogens. The disadvantage is that the absorption of the drug is unstable and not easy to apply. All medications need to be used under a doctor’s supervision.