Paroxysmal gastric colic with diarrhea may be due to acute gastroenteritis, drug factors, according to its cause, symptomatic treatment (antidiarrheal, rehydration), causative treatment (anti-infection, etc.). 1. Acute gastroenteritis: eating bacterial infected food triggered acute gastroenteritis, resulting in paroxysmal gastric colic with diarrhea, can be given norfloxacin, amoxicillin and other anti-infective, combined with montelukast antidiarrheal, bifidobacteria to regulate intestinal flora, rehydration salts and other medications, if the abdominal pain is severe, scopolamine antispasmodic analgesic can be given. 2. Drug factors: taking some statin drugs, such as fluvastatin sodium, antibiotics such as azithromycin, etc. can be gastric colic, diarrhea adverse reactions, in the case of the condition permits, can be discontinued, the application of montelukast antidiarrheal, give vitamins to alleviate the symptoms. Paroxysmal gastric colic with diarrhea, there may be other reasons, it is recommended to consult a doctor in a timely manner, to clarify the diagnosis, and follow the doctor’s instructions to use medication.