Multiple system atrophy is a group of adult-onset, sporadic neurodegenerative disorders characterized by varying degrees of autonomic dysfunction, Parkinson’s syndrome with poor response to levodopa-based medications, cerebellar ataxia, and pyramidal signs. Multiple system atrophy can involve the autonomic nerves, and patients may experience postural hypotension due to autonomic dysfunction, resulting in dizziness and unsteadiness. Multiple system atrophy may involve the cerebellum, resulting in cerebellar ataxia, and therefore a widening of the base of the step when walking, with symptoms such as dizziness, unsteadiness, and unsteady walking. Multiple system atrophy can involve the extrapyramidal system, secondary to Parkinson’s syndrome, and the patient develops bradykinesia, which can lead to symptoms such as limb stiffness and unsteadiness. Currently, the cause of multiple system atrophy is unknown, and once diagnosed, patients should receive targeted treatment under the guidance of a doctor to slow down the progression of the disease.