The origin of obesity: How does sleeve gastric bariatric surgery work? Can reduce weight? Many people think that fat people are eating a lot of food into, in fact, it is not, although diet is a major reason for obesity, but not the root cause of obesity. Obesity is a chronic disease, it includes both internal and external factors, factors affecting: genetic factors, neuropsychiatric factors, hyperinsulinemia, brown adipose tissue abnormalities and so on. Analysis of the internal and external factors triggering obesity: a. External factors external factors to eat too much and too little activity. Caloric intake more than caloric consumption, so that fat synthesis increase is the material basis of obesity; Second, internal factors internal because the human body intrinsic factors make fat metabolism disorder and cause obesity. Including: 1, genetic: one of the two parents is obese, its children obesity rate is about 50%; both parents are obese, its children obesity rate rose to 80%. 2, neuropsychiatric factors: human hypothalamus there are two pairs of nuclei related to feeding behavior. If the ventral medial nucleus is destroyed, the ventral lateral nucleus is relatively hyperfunctional and gluttonous, causing obesity; 3, hyperinsulinemia: obesity often coexists with hyperinsulinemia, but it is generally believed that hyperinsulinemia causes obesity. High insulinemic obesity insulin release is about three times normal; 4, brown adipose tissue abnormal: brown adipose tissue is a kind of adipose tissue, that is, when the body ingestion or cold stimulation, brown adipocyte fat burning, so as to determine the body’s energy metabolism level; 5, other: clinical obesity to more women, especially menstruating women or menopause or oral female contraceptive pill is prone to occur. Suggest estrogen and fat anabolic related. Obesity is a chronic disease, great harm, in addition to seriously affect the work and life, the body is also prone to a variety of complications, such as: hypertension, diabetes, heart disease, fatty liver, coronary heart disease, gout, sleep apnea and other metabolic disorder syndrome. In addition, according to China’s authoritative data survey shows that obesity patients generally reduce life 6 to 7 years, of which serious obesity (BMI greater than 40) to reduce life expectancy of 20 years for men and 5 years for women. At present, there are many products for treating obesity, but they are basically ineffective for obese patients. Minimally invasive surgery is now the dominant modality for long-term effective treatment of obesity. Minimally invasive weight loss procedures include gastric reduction, gastric bypass, gastric banding, and gastric hydrospheresis. Sleeve gastric surgery, or “gastric reduction surgery,” is a hot topic in the bariatric surgery community, and its popularity has increased significantly. Because the surgery will cut off 80% of the stomach volume, in addition to reducing food intake, it will also reduce the secretion of the hormone Ghrelin, which stimulates appetite, and therefore appetite will also be reduced. Within two years after the surgery, about 10-15 BMI or 70% of the excess weight can be lost. For those who have a high BMI (over 40) and have difficulty reducing their appetite, gastric reduction surgery can achieve the desired weight loss.