Left-sided adrenal thickening in women is an imaging change commonly seen with adrenal tumors, adrenal hyperplasia, and adrenal nodules, which do not necessarily require management and need to be evaluated in conjunction with endocrine function labs to determine the decision. Women with left-sided adrenal thickening should be further evaluated for abnormal levels of adrenal hormone secretion, in conjunction with the presence of elevated blood pressure and symptoms such as dizziness. The details are as follows: 1. Combined with endocrine function abnormality: Laboratory results should assess the adrenal cortical and medullary hormone levels, if there is obvious elevation, and the patient has symptoms such as flushing, palpitation, dizziness, etc., it should be further combined with the size and location of the nodule, and then surgery should be performed if necessary. 2. Uncombined endocrine function abnormality: if the laboratory test suggests that the adrenal hormone level is normal, and the patient does not have a clear manifestation of elevated blood pressure, the patient can be followed up on a regular basis, and further treatment can be decided in the light of the follow-up. Therefore, women’s left adrenal gland enlargement does not necessarily need special treatment, but needs to be combined with endocrine function assessment before deciding, the specific follow the doctor’s instructions. It is recommended to carry out standardized examination and treatment under the guidance of regular medical institutions and professional doctors.