If you are still bleeding after taking three boxes of oral dienogest, you should go to the hospital to evaluate the bleeding and change the treatment plan under the doctor’s supervision, such as using levonorgestrel IUD system or gonadotropin-releasing hormone antagonist for treatment. Dienogest is mainly used for the treatment of endometriosis, and the side effects include triggering blood and lymphatic system diseases, metabolic and nutritional disorders, psychiatric disorders, gastrointestinal disorders, reproductive system and breast disorders, and systemic diseases. The drug is contraindicated in venous thrombotic diseases, severe cardiovascular diseases, sex hormone-dependent malignant tumors, hepatic and renal impairment. Note that the risk-benefit for the patient should be assessed before use before starting or continuing the use of Denogestrel tablets. According to the drug insert, changes in bleeding patterns, such as irregular bleeding, spotting, or amenorrhea, may occur during the first 90 days of treatment with Dinogestrel Tablets, most often during the first month after the start of treatment, and gradually diminishing as treatment continues. If vaginal bleeding persists despite taking three boxes of oral Dienogest, prompt medical attention should be sought for further evaluation of the bleeding and treatment with levonorgestrel IUD system or gonadotropin-releasing hormone antagonist, etc., as directed by the doctor.